General Information:

Id: 111
Diseases: Amyotrophic lateral sclerosis
Mus musculus
BTO:0001279 spinal cord
article
Reference: Nishitoh H et al.(2008) ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1 Genes Dev. 22: 1451-1464 [PMID: 18519638]

Interaction Information:

Comment The expression of SOD1(G93A) in neuronal tissues and liver was higher than in other organs and the interaction of Derlin-1 with SOD1mut, but not SOD1wt, was observed specifically in these tissues: liver, cerebral cortex, cerebellum, medulla, and spinal cord.
Formal Description
Interaction-ID: 377

gene/protein mutant

SOD1-p.G93A

interacts (colocalizes) with

gene/protein

DERL1

in spinal cord
Comment SOD1(G93A) exists mainly in the cytosol, and some fraction of SOD1mut attaches to the cytosolic surface of the ER.
Formal Description
Interaction-ID: 379

gene/protein mutant

SOD1-p.G93A

is localized in

cellular component

cytoplasm

mainly
Comment SOD1(G93A) exists mainly in the cytosol, and some fraction of SOD1mut attaches to the cytosolic surface of the ER.
Formal Description
Interaction-ID: 381

gene/protein mutant

SOD1-p.G93A

is localized in

cellular component

endoplasmic reticulum membrane

partly
Comment The expression of SOD1(G93A) in neuronal tissues and liver was higher than in other organs and the interaction of Derlin-1 with SOD1mut, but not SOD1wt, was observed specifically in these tissues: liver, cerebral cortex, cerebellum, medulla, and spinal cord.
Formal Description
Interaction-ID: 13231

gene/protein

SOD1

NOT interacts (colocalizes) with

gene/protein

DERL1

in spinal cord
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