General Information:

Id: 1,107 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Dementia
Mammalia
review
Reference: Candore G et al.(2010) Inflammation, cytokines, immune response, apolipoprotein E, cholesterol, and oxidative stress in Alzheimer disease: therapeutic implications Rejuvenation Res 13: 301-313 [PMID: 20462385]

Interaction Information:

Comment Curcumin is a polyphenolic substance that has the potential to inhibit lipid peroxidation and to effectively intercept and neutralize ROS (superoxide, peroxyl, hydroxyl radicals) and nitric oxide (NO)-based free radicals (nitric oxide and peroxynitrite).
Formal Description
Interaction-ID: 7571

drug/chemical compound

Curcumin

decreases_activity of

process

lipid peroxidation

Comment Curcumin is a polyphenolic substance that has the potential to inhibit lipid peroxidation and to effectively intercept and neutralize ROS (superoxide, peroxyl, hydroxyl radicals) and nitric oxide (NO)-based free radicals (nitric oxide and peroxynitrite).
Formal Description
Interaction-ID: 7574

drug/chemical compound

Curcumin

decreases_activity of

drug/chemical compound

Reactive oxygen species

Comment Of particular interest is the ability of curcumin to inhibit cyclooxygenase enzymes and to reduce the activation of nuclear transcription factor NF-kappaB.
Formal Description
Interaction-ID: 7577

drug/chemical compound

Curcumin

decreases_activity of

Comment Of particular interest is the ability of curcumin to inhibit cyclooxygenase enzymes and to reduce the activation of nuclear transcription factor NF-kappaB.
Formal Description
Interaction-ID: 7579

drug/chemical compound

Curcumin

decreases_activity of

complex/PPI

NF-kappaB complex

Curcumin inhibits cyclooxygenase enzymes and reduces the activation of nuclear transcription factor NF-kappaB.