Kim SR et al.(2010) Prothrombin kringle-2 induces death of mesencephalic dopaminergic neurons in vivo and in vitro via microglial activation J. Neurosci. Res. 88: 1537-1548
[PMID: 20025058]
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Activated microglia produce inflammatory mediators, such as inducible nitric oxide synthase, cyclooxygenase-2 and proinflammatory cytokines, including interleukin 1, IL-6 and tumor necrosis factor alpha. (cited information)