General Information:

Id: 1,103 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Rattus norvegicus
BTO:0000143 substantia nigra
article
Reference: Kim SR et al.(2010) Prothrombin kringle-2 induces death of mesencephalic dopaminergic neurons in vivo and in vitro via microglial activation. J. Neurosci. Res. 88: 1537-1548 [PMID: 20025058]

Interaction Information:

Comment MAPK inhibitors, like JNK inhibitor SP600125 and SB203580 a p38MAPK inhibitor, dramatically attenuate pKr-2-induced mRNA expression of TNF-, iNOS and COX-2 and rescue DA neurons from pKr-2-induced neurotoxicity in the SN in vivo. They do not affect expression of other proinflammatory cytokines examined, like IL-1beta and IL-6.
Formal Description
Interaction-ID: 7143

drug/chemical compound

SP600125

NOT decreases_expression of

gene/protein

IL6

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