General Information:

Id: 1,103 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Rattus norvegicus
BTO:0000143 substantia nigra
article
Reference: Kim SR et al.(2010) Prothrombin kringle-2 induces death of mesencephalic dopaminergic neurons in vivo and in vitro via microglial activation. J. Neurosci. Res. 88: 1537-1548 [PMID: 20025058]

Interaction Information:

Comment pKr-2 induces iNOS, COX-2 and proinflammatory cytokines, like TNFalpha, IL-1beta and IL-6, in microglia in the SN in vivo.
Formal Description
Interaction-ID: 7038

gene/protein

F2

increases_expression of

gene/protein

IL6

via activation of microglia in the substantia nigra
Drugbank entries Show/Hide entries for F2 or IL6