General Information:

Id: 1,101 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Huntington disease - [OMIM]
Rattus norvegicus
BTO:0001009 PC-12 cell
article
Reference: Ravikumar B et al.(2005) Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nat. Genet. 37: 771-776 [PMID: 15980862]

Interaction Information:

Comment The authors used stable inducible neuronal precursor cells lines (PC12) that express two different autophagy substrates, a green fluorescent protein (GFP)-tagged mutant huntingtin fragment encoded by exon 1 with 74 glutamine repeats (Q74-GFP) or A53T alpha-synuclein. Clearance of these transgene products is markedly retarded by inhibition of autophagy. Erythro-9-[3-(2-hydroxynonyl)] adenine (EHNA), a dynein inhibitor, slowed turnover of A53T alpha-synuclein and Q74-GFP. EHNA also increased the numbers of PC12 and COS-7 cells with huntingtin aggregates, consistent with impaired clearance of mutant huntingtin.
Formal Description
Interaction-ID: 6997

complex/PPI

Dynein complex

increases_activity of

process

autophagy