General Information:

Id: 1,093 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Bipolar disorder
Rattus norvegicus
BTO:0004102 cerebral cortical neuron
article
Reference: Shao L et al.(2006) Mood stabilizing drug lithium increases expression of endoplasmic reticulum stress proteins in primary cultured rat cerebral cortical cells. Life Sci. 78: 1317-1323 [PMID: 16236328]

Interaction Information:

Comment Chronic treatment with lithium and valproate, but not carbamazepine and lamotrigine, increase the expression of GRP78 (BiP; HSPA5) , GRP94 and calreticulin.
Formal Description
Interaction-ID: 6942

drug/chemical compound

Lithium

increases_quantity of

gene/protein

HSPA5

Drugbank entries Show/Hide entries for Lithium or HSPA5
Comment Chronic treatment with lithium and valproate, but not carbamazepine and lamotrigine, increase the expression of GRP78, GRP94 (HSP90B1) and calreticulin.
Formal Description
Interaction-ID: 6943

drug/chemical compound

Lithium

increases_quantity of

gene/protein

HSP90B1

Drugbank entries Show/Hide entries for Lithium or HSP90B1
Comment Chronic treatment with lithium and valproate, but not carbamazepine and lamotrigine, increase the expression of GRP78, GRP94 and calreticulin.
Formal Description
Interaction-ID: 6944

drug/chemical compound

Lithium

increases_quantity of

gene/protein

CALR

Drugbank entries Show/Hide entries for Lithium or CALR
Comment Cells were treated with thapsigargin (1 AM) for 30 min, and lithium (1 mM) and valproate (0.6 mM) for 1 week. It was shown that treatment with thapsigargin significantly induced cell death, but chronic treatment with lithium and valproate had no effect on cell viability.
Formal Description
Interaction-ID: 6951

drug/chemical compound

Lithium

NOT affects_activity of

process

cell death

Drugbank entries Show/Hide entries for Lithium