General Information:

Id: 1,092 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
article
Reference: de Luca C and Olefsky JM(2008) Inflammation and insulin resistance FEBS Lett. 582: 97-105 [PMID: 18053812]

Interaction Information:

Comment Nitric oxide (NO) is an endogenous signaling molecule produced by nitric oxide synthase. NO acts as a signal transduction molecule for a number of physiological processes and is involved in many pathophysiologic states, including insulin resistance.
Formal Description
Interaction-ID: 7226

drug/chemical compound

NO

affects_activity of

disease

Insulin resistance

Comment In the insulin signaling pathway, NO can reduce Akt activity by causing s-nitrosylation of a specific cysteine residue.
Formal Description
Interaction-ID: 7242

drug/chemical compound

NO

decreases_activity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1