General Information:

Id: 1,092 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
article
Reference: de Luca C and Olefsky JM(2008) Inflammation and insulin resistance FEBS Lett. 582: 97-105 [PMID: 18053812]

Interaction Information:

Comment Tnf (a.k.a. Tnf-alpha) is a pro-inflammatory cytokine secreted predominantly by monocytes and macrophages. Activation of the Tnf receptor results in stimulation of NF-kappa-B signaling via Ikkb.
Formal Description
Interaction-ID: 7084

gene/protein

TNF

increases_activity of

gene/protein

TNFRSF1A

Drugbank entries Show/Hide entries for TNF or TNFRSF1A
Comment Treatment of cultured 3T3-L1 adipocytes with Tnf leads to reduced expression of the insulin receptor, IRS1 and Glut4 genes, as well as a decrease in insulin stimulated glucose uptake.
Formal Description
Interaction-ID: 7089

gene/protein

TNF

decreases_expression of

gene/protein

INSR

in adipose tissue
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Comment Treatment of cultured 3T3-L1 adipocytes with Tnf leads to reduced expression of the insulin receptor, IRS1 and Glut4 genes, as well as a decrease in insulin stimulated glucose uptake.
Formal Description
Interaction-ID: 7090

gene/protein

TNF

decreases_expression of

gene/protein

IRS1

in adipose tissue
Drugbank entries Show/Hide entries for TNF or IRS1
Comment Treatment of cultured 3T3-L1 adipocytes with Tnf leads to reduced expression of the insulin receptor, IRS1 and Glut4 genes, as well as a decrease in insulin stimulated glucose uptake.
Formal Description
Interaction-ID: 7091

gene/protein

TNF

decreases_expression of

gene/protein

SLC2A4

in adipose tissue
Drugbank entries Show/Hide entries for TNF
Comment Treatment of cultured 3T3-L1 adipocytes with Tnf leads to reduced expression of the insulin receptor, IRS1 and Glut4 genes, as well as a decrease in insulin stimulated glucose uptake.
Formal Description
Interaction-ID: 7092

gene/protein

TNF

decreases_activity of

process

glucose import

in adipose tissue
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Comment A Tnf-induced decrease in 3T3-L1 adipocyte genes has been found, including GLUT4, Hormone Sensitive Lipase (HSL), long-chain fatty acyl CoA synthetase, adiponectin (ADIPOQ), the transcription factor CCAAT/enhancer binding protein-alpha (C/EBP), and the nuclear receptors Pparg and retinoic acid x receptor (RXR). These genes all contribute to glucose homeostasis, both directly and indirectly.
Formal Description
Interaction-ID: 7093

gene/protein

TNF

decreases_expression of

gene/protein

LIPE

in adipose tissue
Drugbank entries Show/Hide entries for TNF
Comment A Tnf-induced decrease in 3T3-L1 adipocyte genes has been found, including GLUT4, Hormone Sensitive Lipase (HSL), long-chain fatty acyl CoA synthetase, adiponectin (ADIPOQ), the transcription factor CCAAT/enhancer binding protein-alpha (C/EBP), and the nuclear receptors Pparg and retinoic acid x receptor (RXR). These genes all contribute to glucose homeostasis, both directly and indirectly.
Formal Description
Interaction-ID: 7095

gene/protein

TNF

decreases_expression of

gene/protein

ACSL

in adipose tissue
Drugbank entries Show/Hide entries for TNF
Comment A Tnf-induced decrease in 3T3-L1 adipocyte genes has been found, including GLUT4, Hormone Sensitive Lipase (HSL), long-chain fatty acyl CoA synthetase, adiponectin (ADIPOQ), the transcription factor CCAAT/enhancer binding protein-alpha (C/EBP), and the nuclear receptors Pparg and retinoic acid x receptor (RXR). These genes all contribute to glucose homeostasis, both directly and indirectly.
Formal Description
Interaction-ID: 7096

gene/protein

TNF

decreases_expression of

gene/protein

ADIPOQ

in adipose tissue
Drugbank entries Show/Hide entries for TNF
Comment A Tnf-induced decrease in 3T3-L1 adipocyte genes has been found, including GLUT4, Hormone Sensitive Lipase (HSL), long-chain fatty acyl CoA synthetase, adiponectin (ADIPOQ), the transcription factor CCAAT/enhancer binding protein-alpha (C/EBP), and the nuclear receptors Pparg and retinoic acid x receptor (RXR). These genes all contribute to glucose homeostasis, both directly and indirectly.
Formal Description
Interaction-ID: 7097

gene/protein

TNF

decreases_expression of

gene/protein

CEBP

in adipose tissue
Drugbank entries Show/Hide entries for TNF
Comment A Tnf-induced decrease in 3T3-L1 adipocyte genes has been found, including GLUT4, Hormone Sensitive Lipase (HSL), long-chain fatty acyl CoA synthetase, adiponectin (ADIPOQ), the transcription factor CCAAT/enhancer binding protein-alpha (C/EBP), and the nuclear receptors Pparg and retinoic acid x receptor (RXR). These genes all contribute to glucose homeostasis, both directly and indirectly.
Formal Description
Interaction-ID: 7098

gene/protein

TNF

decreases_expression of

gene/protein

PPARG

in adipose tissue
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Comment A Tnf-induced decrease in 3T3-L1 adipocyte genes has been found, including GLUT4, Hormone Sensitive Lipase (HSL), long-chain fatty acyl CoA synthetase, adiponectin (ADIPOQ), the transcription factor CCAAT/enhancer binding protein-alpha (C/EBP), and the nuclear receptors Pparg and retinoic acid x receptor (RXR). These genes all contribute to glucose homeostasis, both directly and indirectly.
Formal Description
Interaction-ID: 7099

gene/protein

TNF

decreases_expression of

gene/protein

RXR

in adipose tissue
Drugbank entries Show/Hide entries for TNF
Comment Il-10 is an anti-inflammatory cytokine produced by macrophages and lymphocytes. Il-10 exerts its anti-inflammatory activity by inhibiting Tnf-induced NF-kappa-B activation by reducing IKK activity.
Formal Description
Interaction-ID: 7272

gene/protein

TNF

increases_activity of

Drugbank entries Show/Hide entries for TNF
Comment Adipose tissue macrophages are responsible for nearly all adipose tissue Tnf expression and a significant portion of Nos2 and Il6 expression.
Formal Description
Interaction-ID: 7281

tissue/cell line

adipose tissue macrophage

increases_quantity of

gene/protein

TNF

in adipose tissue
Drugbank entries Show/Hide entries for TNF
Comment Tlr4 belongs to the family of Toll-like receptors that function as pattern recognition receptors that guard against microorganismal infections as part of the innate immune system. Tlr4 is stimulated by lipopolysaccharide (LPS), an endotoxin released by gram-negative bacteria. Tlr4 stimulation results in the activation of both Ikkb/NF-kappa-B and JNK/AP-1 signaling, culminating in the expression and secretion of pro-inflammatory cytokines/chemokines, including, Il1b, IL-6, Tnf, Mcp1.
Formal Description
Interaction-ID: 7327

gene/protein

TLR4

increases_expression of

gene/protein

TNF

Drugbank entries Show/Hide entries for TLR4 or TNF