General Information:

Id: 1,092 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
article
Reference: de Luca C and Olefsky JM(2008) Inflammation and insulin resistance FEBS Lett. 582: 97-105 [PMID: 18053812]

Interaction Information:

Comment Tnf (a.k.a. Tnf-alpha) is a pro-inflammatory cytokine secreted predominantly by monocytes and macrophages. Activation of the Tnf receptor results in stimulation of NF-kappa-B signaling via Ikkb.
Formal Description
Interaction-ID: 7084

gene/protein

TNF

increases_activity of

gene/protein

TNFRSF1A

Drugbank entries Show/Hide entries for TNF or TNFRSF1A