General Information:

Id: 1,092 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Reference: de Luca C and Olefsky JM(2008) Inflammation and insulin resistance FEBS Lett. 582: 97-105 [PMID: 18053812]

Interaction Information:

Comment An additional mediator of insulin action is the heterotrimeric G protein, G-alpha-q/11. Phosphorylation of G-alpha-q/11 by the insulin receptor activates PI3K, thus, stimulating GLUT4-mediated glucose uptake. This signaling pathway is inhibited by G-protein-coupled receptor kinase-2 (Grk2) which binds and inhibits the G-alpha subunit of G-alpha-q/11.
Formal Description
Interaction-ID: 7043


Phosphatidylinositol 3-kinase

increases_activity of


glucose import