General Information:

Id: 1,092 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Reference: de Luca C and Olefsky JM(2008) Inflammation and insulin resistance FEBS Lett. 582: 97-105 [PMID: 18053812]

Interaction Information:

Comment When IRS1 is alternatively phosphorylated on serine 307, its downstream signaling ability is diminished. Serine kinases that phosphorylate serine 307 include I kappa B kinase beta (Ikkb) in the NFkappaB pathway and C-jun N-terminal kinase 1 (Jnk1) in the JNK/AP-1 pathway.
Formal Description
Interaction-ID: 6984

protein modification


decreases_activity of