General Information:

Id: 1,092 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
article
Reference: de Luca C and Olefsky JM(2008) Inflammation and insulin resistance FEBS Lett. 582: 97-105 [PMID: 18053812]

Interaction Information:

Comment Increased circulating FFA can result in decreased insulin sensitivity in skeletal muscle due to an increase in intracellular lipid products, including fatty acyl-CoA and ceramide. These lipid intermediates can activate the serine/threonine kinase, protein kinase C-theta (PKC-theta), which then inhibits the insulin signaling cascade.
Formal Description
Interaction-ID: 6962

gene/protein

PRKCQ

decreases_activity of

in skeletal muscle
Drugbank entries Show/Hide entries for PRKCQ
Comment The insulin signaling cascade branches off into two main pathways, the first is the phosphatidylinositol 3-kinase (PI3K)-AKT (also called protein kinase B (PKB)) pathway which is largely responsible for insulin action on glucose uptake, as well as other metabolic actions of insulin, including the suppression of gluconeogenesis. The second pathway is the Ras-mitogen activated protein kinase (MAPK) pathway which mediates gene expression, but also interacts with the PI3K-AKT pathway to control cell growth and differentiation.
Formal Description
Interaction-ID: 6964
Comment The insulin signaling cascade branches off into two main pathways, the first is the phosphatidylinositol 3-kinase (PI3K)-AKT (also called protein kinase B (PKB)) pathway which is largely responsible for insulin action on glucose uptake, as well as other metabolic actions of insulin, including the suppression of gluconeogenesis. The second pathway is the Ras-mitogen activated protein kinase (MAPK) pathway which mediates gene expression, but also interacts with the PI3K-AKT pathway to control cell growth and differentiation.
Formal Description
Interaction-ID: 6968
Comment Activation of the insulin receptor leads to tyrosine phosphorylation of IRS1 thereby initiating signal transduction.
Formal Description
Interaction-ID: 6981

protein modification

IRS1-phosTyr

increases_activity of

Comment When IRS1 is alternatively phosphorylated on serine 307, its downstream signaling ability is diminished. Serine kinases that phosphorylate serine 307 include I kappa B kinase beta (Ikkb) in the NFkappaB pathway and C-jun N-terminal kinase 1 (Jnk1) in the JNK/AP-1 pathway.
Formal Description
Interaction-ID: 6984

protein modification

IRS1-phosSer307

decreases_activity of