General Information:

Id: 1,092 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Reference: de Luca C and Olefsky JM(2008) Inflammation and insulin resistance FEBS Lett. 582: 97-105 [PMID: 18053812]

Interaction Information:

Comment In skeletal muscle insulin promotes glucose uptake by stimulating translocation of the GLUT4 glucose transporter to the plasma membrane, and impaired skeletal muscle insulin signaling results in decreased glucose disposal.
Formal Description
Interaction-ID: 6925


Insulin resistance

decreases_activity of


glucose import

in skeletal muscle