General Information:

Id: 1,089
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD-G93A mouse
article
Reference: Fornai F et al.(2008) Lithium delays progression of amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. U.S.A. 105: 2052-2057 [PMID: 18250315]

Interaction Information:

Comment In SOD-G93A mice, lithium treatment prolonged the mean survival time from 110.8 days to 148 and, most importantly, increased disease duration (from a mean of 9 days to 38 days) compared with the G93A mice treated with saline.
Formal Description
Interaction-ID: 6902

drug/chemical compound

Lithium

decreases_activity of

disease

Amyotrophic lateral sclerosis

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Comment Application of lithium in SOD-G93A mice resulted in decreased astrocytosis, decreased alpha-synuclein, ubiquitin, and SOD1 aggregation.
Formal Description
Interaction-ID: 6904

drug/chemical compound

Lithium

decreases_activity of

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Comment Application of lithium in SOD-G93A mice resulted in a higher number of interneurons even when compared with control mice.
Formal Description
Interaction-ID: 6905

drug/chemical compound

Lithium

increases_quantity of

tissue/cell line

interneuron

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Comment Application of lithium in SOD-G93A mice increases the number of autophagic vacuoles. When lithium was administered, there was a marked increase in autophagy vacuoles as confirmed by ImmunoGold-conjugated autophagy markers, such as beclin or the microtubule-associated protein 1 light chain 3 (LC3).
Formal Description
Interaction-ID: 6907

drug/chemical compound

Lithium

increases_activity of

process

autophagy

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Comment Application of lithium in SOD-G93A mice given 20 min before kinate fully protected G93A neurons.
Formal Description
Interaction-ID: 6908

drug/chemical compound

Lithium

decreases_activity of

drug/chemical compound

Kainic acid

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