General Information:

Id: 1,089 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD-G93A mouse
article
Reference: Fornai F et al.(2008) Lithium delays progression of amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. U.S.A. 105: 2052-2057 [PMID: 18250315]

Interaction Information:

Comment Application of lithium in SOD-G93A mice increases the number of autophagic vacuoles. When lithium was administered, there was a marked increase in autophagy vacuoles as confirmed by ImmunoGold-conjugated autophagy markers, such as beclin or the microtubule-associated protein 1 light chain 3 (LC3).
Formal Description
Interaction-ID: 6907

drug/chemical compound

Lithium

increases_activity of

process

autophagy

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