CIDeRGeneral Information:
| Id: | 1,086 (click here to show other Interactions for entry) |
| Diseases: |
Parkinson disease
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| Mus musculus | |
| BTO:0000099 astrocyte | |
| article | |
| Reference: | Waak J et al.(2009) Regulation of astrocyte inflammatory responses by the Parkinsons disease-associated gene DJ-1 FASEB J. 23: 2478-2489 [PMID: 19276172] |
Interaction Information:
| Comment | Bacterial endotoxin LPS triggers neuroinflammatory response in astrocytes. |
|
Formal Description Interaction-ID: 6884 |
drug/chemical compound increases_activity of process |
| Comment | LPS stimulated transient phosphorylation of the stress-activated protein kinases JNK and p38MAPK. Phosphorylation was significantly stronger in Dj-1-/- astrocyte cultures. Thus, the p38MAPK pathway may be specifically involved in the DJ-1-regulated astrocyte inflammatory responses. |
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Formal Description Interaction-ID: 6930 |
gene/protein affects_activity of process |
| Drugbank entries | Show/Hide entries for PARK7 |
| Comment | A second LPS-inducible enzyme generating proinflammatory mediators is COX-2, which produces prostaglandin E2 and is believed to contribute to neuroinflammatory processes in PD, like iNOS. |
|
Formal Description Interaction-ID: 6936 |
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| Drugbank entries | Show/Hide entries for PTGS2 |
| Comment | A second LPS-inducible enzyme generating proinflammatory mediators is COX-2, which produces prostaglandin E2 and is believed to contribute to neuroinflammatory processes in PD, like iNOS. |
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Formal Description Interaction-ID: 6937 |
|
| Comment | LPS stimulated transient phosphorylation of the stress-activated protein kinases JNK and p38MAPK. Phosphorylation was significantly stronger in Dj-1-/- astrocyte cultures. Thus, the p38MAPK pathway may be specifically involved in the DJ-1-regulated astrocyte inflammatory responses. |
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Formal Description Interaction-ID: 8543 |
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