General Information:

Id: 1,086 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
BTO:0000099 astrocyte
article
Reference: Waak J et al.(2009) Regulation of astrocyte inflammatory responses by the Parkinsons disease-associated gene DJ-1 FASEB J. 23: 2478-2489 [PMID: 19276172]

Interaction Information:

Comment Dj-1-/- astrocytes produced 10 times more NO in response to LPS compared with wild-type controls and reverted to wild-type levels after transduction of DJ-1.
Formal Description
Interaction-ID: 6887

gene/protein

PARK7

decreases_quantity of

drug/chemical compound

NO

in response to LPS, via p38MAPK pathway
Drugbank entries Show/Hide entries for PARK7
Comment Dj-1-/- astrocytes produced 10 times more NO in response to LPS compared with wild-type controls and reverted to wild-type levels after transduction of DJ-1.
Formal Description
Interaction-ID: 6892

drug/chemical compound

Lipopolysaccharide

increases_quantity of

drug/chemical compound

NO

Comment Loss of DJ-1 leads to excessive iNOS-mediated NO production in primary astrocyte cultures.
Formal Description
Interaction-ID: 6893

gene/protein

NOS2

increases_quantity of

drug/chemical compound

NO

Drugbank entries Show/Hide entries for NOS2
Comment Loss of DJ-1 leads to excessive iNOS-mediated NO production in primary astrocyte cultures.
Formal Description
Interaction-ID: 6894

gene/protein

PARK7

decreases_quantity of

drug/chemical compound

NO

Drugbank entries Show/Hide entries for PARK7