General Information:

Id: 1,086 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
BTO:0000099 astrocyte
article
Reference: Waak J et al.(2009) Regulation of astrocyte inflammatory responses by the Parkinsons disease-associated gene DJ-1 FASEB J. 23: 2478-2489 [PMID: 19276172]

Interaction Information:

Comment Bacterial endotoxin LPS triggers neuroinflammatory response in astrocytes.
Formal Description
Interaction-ID: 6884

drug/chemical compound

Lipopolysaccharide

increases_activity of

in astrocytes
Comment LPS stimulated transient phosphorylation of the stress-activated protein kinases JNK and p38MAPK. Phosphorylation was significantly stronger in Dj-1-/- astrocyte cultures. Thus, the p38MAPK pathway may be specifically involved in the DJ-1-regulated astrocyte inflammatory responses.
Formal Description
Interaction-ID: 6930

gene/protein

PARK7

affects_activity of

in astrocytes; via p38MAPK pathway
Drugbank entries Show/Hide entries for PARK7
Comment A second LPS-inducible enzyme generating proinflammatory mediators is COX-2, which produces prostaglandin E2 and is believed to contribute to neuroinflammatory processes in PD, like iNOS.
Formal Description
Interaction-ID: 6936

gene/protein

PTGS2

affects_activity of

via Prostaglandin production
Drugbank entries Show/Hide entries for PTGS2
Comment A second LPS-inducible enzyme generating proinflammatory mediators is COX-2, which produces prostaglandin E2 and is believed to contribute to neuroinflammatory processes in PD, like iNOS.
Formal Description
Interaction-ID: 6937

increases_activity of

disease

Parkinson disease

Comment LPS stimulated transient phosphorylation of the stress-activated protein kinases JNK and p38MAPK. Phosphorylation was significantly stronger in Dj-1-/- astrocyte cultures. Thus, the p38MAPK pathway may be specifically involved in the DJ-1-regulated astrocyte inflammatory responses.
Formal Description
Interaction-ID: 8543

increases_activity of