General Information:

Id: 1,083 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
MCK-hPTP1B: transgenic mouse overexpressing human PTP1B selectively in muscle at levels similar to those observed in insulin-resistant humans
article
Reference: Zabolotny JM et al.(2004) Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action J. Biol. Chem. 279 [PMID: 15031294]

Interaction Information:

Comment Hyperinsulinemic-euglycemic clamp studies revealed that whole body glucose disposal and muscle glucose uptake were decreased by 40-50% in PTP1B-overexpressing mice.
Formal Description
Interaction-ID: 6915

gene/protein

PTPN1

decreases_activity of

process

glucose import

if human PTPN1 is selectively overexpressed in muscles of mice at levels similar to those observed in insulin-resistant humans
Drugbank entries Show/Hide entries for PTPN1