General Information:

Id: 1,083 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
MCK-hPTP1B: transgenic mouse overexpressing human PTP1B selectively in muscle at levels similar to those observed in insulin-resistant humans
article
Reference: Zabolotny JM et al.(2004) Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action J. Biol. Chem. 279 [PMID: 15031294]

Interaction Information:

Comment Overexpression of protein-tyrosine phosphatase 1B (PTP1B) or leukocyte antigen-related phosphatase (LAR) alone in muscle caused similar impairments in insulin action; however, compound overexpression achieved by crossing PTP1B- and LAR-overexpressing mice was not additive.
Formal Description
Interaction-ID: 13232

gene/protein

PTPN1

affects_activity of

if PTPN1 is overexpressed in muscle
Drugbank entries Show/Hide entries for PTPN1