General Information:

Id: 1,081
Diseases: Neurological
Mus musculus
BTO:0001958 embryonic fibroblast cell line; BTO:0000944 NIH-3T3 cell
article
Reference: Stambolic V et al.(1998) Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95: 29-39 [PMID: 9778245]

Interaction Information:

Comment PTEN-deficient mouse embryonic fibroblasts exhibit decreased sensitivity to apoptosis. Expression of exogenous mPTEN restores sensitivity to apoptosis.
Formal Description
Interaction-ID: 6846

gene/protein

PTEN

increases_activity of

Comment PKB/Akt is implicated in protection from apoptosis.
Formal Description
Interaction-ID: 6847

gene/protein

AKT1

decreases_activity of

Drugbank entries Show/Hide entries for AKT1
Comment PTEN dephosphorylates phosphatidylinositol(3,4,5)P3 (PIP3), resulting in inhibition of the PI3K pathway.
Formal Description
Interaction-ID: 6848

gene/protein

PTEN

decreases_phosphorylation of

Comment PTEN dephosphorylates phosphatidylinositol(3,4,5)P3 (PIP3), resulting in inhibition of the PI3K pathway.
Formal Description
Interaction-ID: 6849

gene/protein

PTEN

decreases_activity of

Comment PTEN dephosphorylates phosphatidylinositol(3,4,5)P3 (PIP3), resulting in a reduced activity of the PI3K pathway and PDK/AKT signaling.
Formal Description
Interaction-ID: 6850

gene/protein

PTEN

decreases_activity of