General Information:

Id: 107 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
BTO:0000233 cerebral cortex
article
Reference: Nishitoh H et al.(2008) ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1 Genes Dev. 22: 1451-1464 [PMID: 18519638]

Interaction Information:

Comment The expression of SOD1(G93A) in neuronal tissues and liver was higher than in other organs and the interaction of Derlin-1 with SOD1mut, but not SOD1wt, was observed specifically in these tissues: liver, cerebral cortex, cerebellum, medulla, and spinal cord.
Formal Description
Interaction-ID: 372

gene/protein mutant

SOD1-p.G93A

interacts (colocalizes) with

gene/protein

DERL1

in cerebral cortex