General Information:

Id: 1,071 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1G93A transgenic mouse, transfected with human SOD1G93A, treated with APC (activated protein C (anticoagulant protein C))
article
Reference: Zhong Z et al.(2009) Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells J. Clin. Invest. 119: 3437-3449 [PMID: 19841542]

Interaction Information:

Comment APC downregulates mutant SOD1 in microglia and delays an inflammatory response. 5A-APC (mutant having 10% of the anticoagulant activity of WT-APC but retaining normal cytoprotective activity) treatment effectively reduced the expression of inflammatory markers, including monocyte chemoattractant protein 1 MCP-1 and Icam-1, a neuroinflammatory marker of activated endothelium.
Formal Description
Interaction-ID: 7461

gene/protein mutant

PROC-mut

decreases_activity of

in lumbar spinal cord