General Information:

Id: 1,070 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell
article
Reference: Lev N et al.(2009) DJ-1 protects against dopamine toxicity. J Neural Transm 116: 151-160 [PMID: 18974921]

Interaction Information:

Comment Exposure of cells to dopamine caused increased intracellular ROS levels. Overexpression of DJ-1 significantly reduced intracellular ROS accumulation after dopamine exposure.
Formal Description
Interaction-ID: 6742

drug/chemical compound

Dopamine

increases_quantity of

drug/chemical compound

Reactive oxygen species

Drugbank entries Show/Hide entries for Dopamine
Comment Exposure of cells to dopamine caused increased intracellular ROS levels. Overexpression of DJ-1 significantly reduced intracellular ROS accumulation after dopamine exposure.
Formal Description
Interaction-ID: 6743

gene/protein

PARK7

decreases_quantity of

drug/chemical compound

Reactive oxygen species

Drugbank entries Show/Hide entries for PARK7
Comment Dopamine exposure leads to ROS-mediated upregulation of DJ-1.
Formal Description
Interaction-ID: 6744

drug/chemical compound

Reactive oxygen species

increases_quantity of

gene/protein

PARK7

Drugbank entries Show/Hide entries for PARK7