General Information:

Id: 1,068 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
BTO:0003037 HT-22 cell
article
Reference: Sun KH et al.(2008) Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction J. Neurochem. 107: 265-278 [PMID: 18691386]

Interaction Information:

Comment Cdk5 is a key enzyme that promotes ROS accumulation upon glutamate stimulation. Inhibition of Cdk5 leads to reduction of ROS accumulation in primary neurons upon Abeta and glutamate stimulation.
Formal Description
Interaction-ID: 6840

gene/protein

CDK5

affects_quantity of

drug/chemical compound

Reactive oxygen species

depending of glutamate stimulation
Drugbank entries Show/Hide entries for CDK5
Comment Glutamate stimulation increased ROS levels.
Formal Description
Interaction-ID: 6841

drug/chemical compound

Glutamate

increases_quantity of

drug/chemical compound

Reactive oxygen species

Comment Abeta(25-35) treatment resulted in more than 2.5-fold increase in ROS levels in primary cortical cells, which was Cdk5-dependent.
Formal Description
Interaction-ID: 6843

increases_quantity of

drug/chemical compound

Reactive oxygen species

2.5-fold increase in ROS levels, Cdk5-dependent