General Information:

Id: 1,065
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell; BTO:0000298 COS-7 cell
article
Reference: Junn E et al.(2005) Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. Proc. Natl. Acad. Sci. U.S.A. 102: 9691-9696 [PMID: 15983381]

Interaction Information:

Comment DJ-1 protects cells against oxidative stress.
Formal Description
Interaction-ID: 6687

increases_activity of

process

neuron death

Comment DJ-1 protects cells against oxidative stress.
Formal Description
Interaction-ID: 6706

gene/protein

PARK7

decreases_activity of

Drugbank entries Show/Hide entries for PARK7
Comment DJ-1 protects cells against oxidative stress. The pathogenic mutation L166P was totally ineffective in protecting cells against oxidative stress.
Formal Description
Interaction-ID: 6707

gene/protein

PARK7

decreases_activity of

process

neuron death

induced by oxidative stress (triggered by H2O2, dopamine or MPTP)
Drugbank entries Show/Hide entries for PARK7
Comment DJ-1 protects cells against oxidative stress. The pathogenic mutation L166P was totally ineffective in protecting cells against oxidative stress.
Formal Description
Interaction-ID: 6709

gene/protein mutant

PARK7-p.L166P

NOT decreases_activity of

process

neuron death

induced by oxidative stress
Comment DJ-1 overexpression was associated with lower H2O2 levels even in the absence of exogenous H2O2, consistent with an antioxidant activity of DJ-1.
Formal Description
Interaction-ID: 6710

gene/protein

PARK7

decreases_quantity of

drug/chemical compound

H2O2

Drugbank entries Show/Hide entries for PARK7
Comment In a yeast two-hybrid screen DJ-1 interacts with UBA2, SUMO1, UBC9, DAXX and DJ-1 itself, suggesting that DJ-1 may act as homodimer.
Formal Description
Interaction-ID: 6711

gene/protein

PARK7

interacts (colocalizes) with

gene/protein

UBA2

Drugbank entries Show/Hide entries for PARK7
Comment In a yeast two-hybrid screen DJ-1 interacts with UBA2, SUMO1, UBC9, DAXX and DJ-1 itself, suggesting that DJ-1 may act as homodimer.
Formal Description
Interaction-ID: 6712

gene/protein

PARK7

interacts (colocalizes) with

gene/protein

SUMO1

Drugbank entries Show/Hide entries for PARK7
Comment In a yeast two-hybrid screen DJ-1 interacts with UBA2, SUMO1, UBC9, DAXX and DJ-1 itself, suggesting that DJ-1 may act as homodimer.
Formal Description
Interaction-ID: 6713

gene/protein

PARK7

interacts (colocalizes) with

gene/protein

UBE2I

Drugbank entries Show/Hide entries for PARK7
Comment In a yeast two-hybrid screen DJ-1 interacts with UBA2, SUMO1, UBC9, DAXX and DJ-1 itself, suggesting that DJ-1 may act as homodimer.
Formal Description
Interaction-ID: 6714

gene/protein

PARK7

interacts (colocalizes) with

gene/protein

DAXX

Drugbank entries Show/Hide entries for PARK7
Comment In a yeast two-hybrid screen DJ-1 interacts with UBA2, SUMO1, UBC9, DAXX and DJ-1 itself, suggesting that DJ-1 may act as homodimer.
Formal Description
Interaction-ID: 6715

gene/protein

PARK7

interacts (colocalizes) with

gene/protein

PARK7

Drugbank entries Show/Hide entries for PARK7 or PARK7
Comment In a yeast two-hybrid screen DJ-1 does not interact with alpha-synuclein.
Formal Description
Interaction-ID: 6716

gene/protein

PARK7

NOT interacts (colocalizes) with

gene/protein

SNCA

Drugbank entries Show/Hide entries for PARK7
Comment The interaction of Daxx to the mutant was much weaker than to wild-type DJ-1.
Formal Description
Interaction-ID: 6717

gene/protein mutant

PARK7-p.L166P

NOT interacts (colocalizes) with

gene/protein

DAXX

Comment Daxx interacts with ASK1, causing activation of this kinase, which subsequently promotes cell death.
Formal Description
Interaction-ID: 6718

gene/protein

DAXX

interacts (colocalizes) with

gene/protein

MAP3K5

Comment Daxx interacts with ASK1, causing activation of this kinase, which subsequently promotes cell death.
Formal Description
Interaction-ID: 6719

gene/protein

DAXX

increases_activity of

gene/protein

MAP3K5

Comment Daxx interacts with ASK1, causing activation of this kinase, which subsequently promotes cell death.
Formal Description
Interaction-ID: 6720

gene/protein

MAP3K5

increases_activity of

process

neuron death

if ASK1 has been activated by DAXX
Comment DJ-1 markedly inhibited Daxx-induced ASK1 activation, whereas the L166P mutant was incapable of repressing the activation of this kinase.
Formal Description
Interaction-ID: 6723

gene/protein

PARK7

decreases_activity of

gene/protein

MAP3K5

after activation of ASK1 by DAXX
Drugbank entries Show/Hide entries for PARK7
Comment DJ-1 markedly inhibited Daxx-induced ASK1 activation, whereas the L166P mutant was incapable of repressing the activation of this kinase.
Formal Description
Interaction-ID: 6724

gene/protein mutant

PARK7-p.L166P

NOT decreases_activity of

gene/protein

MAP3K5

after activation of ASK1 by DAXX
Comment ASK1 is activated by oxidative stress.
Formal Description
Interaction-ID: 6725

increases_activity of

gene/protein

MAP3K5

Comment DJ-1 sequesters DAXX in the nucleus, thereby preventing it from gaining access to the cytoplasm, from binding to and activating its effector kinase ASK1.
Formal Description
Interaction-ID: 6727

gene/protein

PARK7

decreases_activity of

process

neuron death

by sequestering DAXX in the nucleus
Drugbank entries Show/Hide entries for PARK7
Comment Daxx interacts with ASK1, causing activation of this kinase, which subsequently promotes cell death.
Formal Description
Interaction-ID: 6730

gene/protein

DAXX

increases_activity of

process

neuron death

by interacting with ASK1, thereby increasing the activity of ASK1