General Information:

Id: 1,059 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0002181 HEK-293T cell; BTO:0000793 SH-SY5Y cell
article
Reference: Mo JS et al.(2010) DJ-1 modulates the p38 mitogen-activated protein kinase pathway through physical interaction with apoptosis signal-regulating kinase 1. J. Cell. Biochem. 110: 229-237 [PMID: 20213747]

Interaction Information:

Comment Exposing the cells to H2O2 increased p38, the key enzyme of the stress-activated MAPK signaling, activity and this effect was inhibited by the over-expression of DJ-1.
Formal Description
Interaction-ID: 6614

drug/chemical compound

H2O2

increases_activity of

gene/protein

p38 MAPK