General Information:

Id: 1,059
Diseases: Parkinson disease
Homo sapiens
BTO:0002181 HEK-293T cell; BTO:0000793 SH-SY5Y cell
article
Reference: Mo JS et al.(2010) DJ-1 modulates the p38 mitogen-activated protein kinase pathway through physical interaction with apoptosis signal-regulating kinase 1. J. Cell. Biochem. 110: 229-237 [PMID: 20213747]

Interaction Information:

Comment DJ-1 suppresses oxidative stress-induced ASK1 activation.
Formal Description
Interaction-ID: 6610

gene/protein

PARK7

decreases_activity of

gene/protein

MAP3K5

during oxidative stress
Drugbank entries Show/Hide entries for PARK7
Comment H2O2 induces activation of ASK1.
Formal Description
Interaction-ID: 6611

drug/chemical compound

H2O2

increases_activity of

gene/protein

MAP3K5

Comment DJ-1 expression inhibited H2O2-induced MKK3 activation only indirect by inhibiting ASK1.
Formal Description
Interaction-ID: 6612

drug/chemical compound

H2O2

increases_activity of

gene/protein

MAP2K3

Comment Exposing the cells to H2O2 increased p38, the key enzyme of the stress-activated MAPK signaling, activity and this effect was inhibited by the over-expression of DJ-1.
Formal Description
Interaction-ID: 6614

drug/chemical compound

H2O2

increases_activity of

gene/protein

p38 MAPK

Comment DJ-1 inhibits the ASK1-dependent transactivation activity of ATF2.
Formal Description
Interaction-ID: 6618

gene/protein

PARK7

decreases_activity of

gene/protein

ATF2

by inhibiting ASK1
Drugbank entries Show/Hide entries for PARK7
Comment DJ-1 was not phosphorylated by ASK1.
Formal Description
Interaction-ID: 6624

gene/protein

MAP3K5

NOT increases_phosphorylation of

gene/protein

PARK7

Drugbank entries Show/Hide entries for PARK7
Comment DJ-1 interacts with ASK1 and disrupts ASK1 homodimerization, thus inhibiting ASK1 activity.
Formal Description
Interaction-ID: 6628

gene/protein

PARK7

interacts (colocalizes) with

gene/protein

MAP3K5

Drugbank entries Show/Hide entries for PARK7
Comment Exposing the cells to H2O2 increased p38 activity and this effect was inhibited by the over-expression of DJ-1.
Formal Description
Interaction-ID: 6818

gene/protein

PARK7

decreases_activity of

gene/protein

p38 MAPK

after H2O2 treatment
Drugbank entries Show/Hide entries for PARK7
Comment Exposing the cells to H2O2 increased p38 activity, the key enzyme of the stress-activated MAPK signaling, and this effect was inhibited by the over-expression of DJ-1.
Formal Description
Interaction-ID: 6819

gene/protein

PARK7

decreases_activity of

after H2O2 treatment
Drugbank entries Show/Hide entries for PARK7
Comment Exposing the cells to H2O2 increased p38 activity, the key enzyme of the stress-activated MAPK signaling, and this effect was inhibited by the over-expression of DJ-1.
Formal Description
Interaction-ID: 6820

gene/protein

p38 MAPK

increases_activity of

after H2O2 treatment
Comment Exposing the cells to H2O2 increased p38 activity, the key enzyme of the stress-activated MAPK signaling, and this effect was inhibited by the over-expression of DJ-1.
Formal Description
Interaction-ID: 13604

drug/chemical compound

H2O2

increases_activity of