General Information:

Id: 1,057 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
PS cDKO mouse (= double knock-out mice lacking both presenilins in the postnatal forebrain)
brain
article
Reference: Beglopoulos V et al.(2004) Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. J. Biol. Chem. 279 [PMID: 15345711]

Interaction Information:

Comment The results indicate that the memory impairment and neurodegeneration in PS cDKO mice are not caused by Abeta accumulation and that loss of PS function leads to differential up-regulation of inflammatory markers in the cerebral cortex.
Formal Description
Interaction-ID: 6606

organism model

PS cDKO mouse

increases_activity of

in neocortex and hippocampus