General Information:

Id: 1,042 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
neuronal Ptpn1(-/-) mouse
article
Reference: Bence KK et al.(2006) Neuronal PTP1B regulates body weight, adiposity and leptin action Nat. Med. 12: 917-924 [PMID: 16845389]

Interaction Information:

Comment Hypothalamic leptin signaling was increased in neuronal Ptpn1(-/-) mice, as indicated by their enhanced fasting and leptin evoked phosphorylation of Stat3 in the hypothalamus.
Formal Description
Interaction-ID: 6528

gene/protein

LEP

increases_phosphorylation of

gene/protein

STAT3

in hypothalamus; if PTPN1 is knocked out in neurons
Comment Adiponectin levels were elevated in neuronal Ptpn1(-/-) mice, consistent with their lean phenotype, whereas leptin levels were inappropriately high and resistin levels were unexpectedly normal.
Formal Description
Interaction-ID: 6534

gene/protein

PTPN1

affects_quantity of

gene/protein

LEP

if PTPN1 is knocked out in neurons
Drugbank entries Show/Hide entries for PTPN1