General Information:

Id: 1,042
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
neuronal Ptpn1(-/-) mouse
article
Reference: Bence KK et al.(2006) Neuronal PTP1B regulates body weight, adiposity and leptin action Nat. Med. 12: 917-924 [PMID: 16845389]

Interaction Information:

Comment Neuronal Ptpn1(-/-) mice have reduced weight and adiposity, and increased activity and energy expenditure. In contrast, adipose PTP1B deficiency increases body weight, whereas PTP1B deletion in muscle or liver does not affect weight.
Formal Description
Interaction-ID: 6517

gene/protein

PTPN1

affects_activity of

disease

Obesity

if PTPN1 is knocked out in neurons
Drugbank entries Show/Hide entries for PTPN1
Comment Neuronal Ptpn1(-/-) mice have reduced weight and adiposity, and increased activity and energy expenditure. In contrast, adipose PTP1B deficiency increases body weight, whereas PTP1B deletion in muscle or liver does not affect weight.
Formal Description
Interaction-ID: 6522

gene/protein

PTPN1

increases_activity of

disease

Obesity

if PTPN1 is knocked out in adipose tissue
Drugbank entries Show/Hide entries for PTPN1
Comment Neuronal Ptpn1(-/-) mice have reduced weight and adiposity, and increased activity and energy expenditure. In contrast, adipose PTP1B deficiency increases body weight, whereas PTP1B deletion in muscle or liver does not affect weight.
Formal Description
Interaction-ID: 6524

gene/protein

PTPN1

NOT affects_activity of

disease

Obesity

if PTPN1 is knocked out in muscle or liver
Drugbank entries Show/Hide entries for PTPN1
Comment Hypothalamic leptin signaling was increased in neuronal Ptpn1(-/-) mice, as indicated by their enhanced fasting and leptin evoked phosphorylation of Stat3 in the hypothalamus.
Formal Description
Interaction-ID: 6526

gene/protein

PTPN1

affects_activity of

in hypothalamus; if PTPN1 is knocked out in neurons
Drugbank entries Show/Hide entries for PTPN1
Comment Hypothalamic leptin signaling was increased in neuronal Ptpn1(-/-) mice, as indicated by their enhanced fasting and leptin evoked phosphorylation of Stat3 in the hypothalamus.
Formal Description
Interaction-ID: 6527

gene/protein

PTPN1

increases_phosphorylation of

gene/protein

STAT3

in hypothalamus; if PTPN1 is knocked out in neuronsvia leptin signaling,
Drugbank entries Show/Hide entries for PTPN1
Comment Hypothalamic leptin signaling was increased in neuronal Ptpn1(-/-) mice, as indicated by their enhanced fasting and leptin evoked phosphorylation of Stat3 in the hypothalamus.
Formal Description
Interaction-ID: 6528

gene/protein

LEP

increases_phosphorylation of

gene/protein

STAT3

in hypothalamus; if PTPN1 is knocked out in neurons
Comment Adiponectin levels were elevated in neuronal Ptpn1(-/-) mice, consistent with their lean phenotype, whereas leptin levels were inappropriately high and resistin levels were unexpectedly normal.
Formal Description
Interaction-ID: 6531

gene/protein

PTPN1

affects_quantity of

gene/protein

ADIPOQ

if PTPN1 is knocked out in neurons
Drugbank entries Show/Hide entries for PTPN1
Comment Adiponectin levels were elevated in neuronal Ptpn1(-/-) mice, consistent with their lean phenotype, whereas leptin levels were inappropriately high and resistin levels were unexpectedly normal.
Formal Description
Interaction-ID: 6534

gene/protein

PTPN1

affects_quantity of

gene/protein

LEP

if PTPN1 is knocked out in neurons
Drugbank entries Show/Hide entries for PTPN1
Comment Adiponectin levels were elevated in neuronal Ptpn1(-/-) mice, consistent with their lean phenotype, whereas leptin levels were inappropriately high and resistin levels were unexpectedly normal.
Formal Description
Interaction-ID: 6535

gene/protein

PTPN1

NOT affects_quantity of

gene/protein

RETN

if PTPN1 is knocked out in neurons
Drugbank entries Show/Hide entries for PTPN1
Comment Male neuronal Ptpn1(-/-) mice showed improved insulin sensitivity, and enhanced glucose tolerance, compared to littermate controls.
Formal Description
Interaction-ID: 6536

gene/protein

PTPN1

affects_activity of

in males, if PTPN1 is knocked out in neurons
Drugbank entries Show/Hide entries for PTPN1
Comment Improved insulin sensitivity was accompanied by increased insulin receptor phosphorylation in muscle and liver in male neuronal Ptpn1(-/-) mice.
Formal Description
Interaction-ID: 6537

gene/protein

PTPN1

affects_phosphorylation of

complex/PPI

Insulin receptor

in muscle, in liver; in males, if PTPN1 is knocked out in neurons
Drugbank entries Show/Hide entries for PTPN1
Comment Improved insulin sensitivity was accompanied by increased insulin receptor phosphorylation in muscle and liver in male neuronal Ptpn1(-/-) mice.
Formal Description
Interaction-ID: 13214

gene/protein

PTPN1

affects_activity of

in muscle, in liver; in males, if PTPN1 is knocked out in neurons
Drugbank entries Show/Hide entries for PTPN1