General Information:

Id: 1,037 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Lam NT et al.(2006) Leptin resistance following over-expression of protein tyrosine phosphatase 1B in liver. J. Mol. Endocrinol. 36: 163-174 [PMID: 16461936]

Interaction Information:

Comment Increased PTP1B expression in livers of ob/ob mice inhibits the effects of leptin on food consumption and blood glucose concentrations.
Formal Description
Interaction-ID: 6509

gene/protein

PTPN1

decreases_activity of

gene/protein

LEP

if PTPN1 is overexpressed
Drugbank entries Show/Hide entries for PTPN1