General Information:

Id: 1,037
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Lam NT et al.(2006) Leptin resistance following over-expression of protein tyrosine phosphatase 1B in liver. J. Mol. Endocrinol. 36: 163-174 [PMID: 16461936]

Interaction Information:

Comment High fat feeding induces hyperglycemia, hyperinsulinemia and hyperleptinemia in C57BL/6 mice.
Formal Description
Interaction-ID: 6498

environment

high-fat diet

increases_quantity of

drug/chemical compound

Glucose

in blood
Comment High fat feeding induces hyperglycemia, hyperinsulinemia and hyperleptinemia in C57BL/6 mice.
Formal Description
Interaction-ID: 6500

environment

high-fat diet

increases_quantity of

complex/PPI

Insulin

in blood
Comment High fat feeding induces hyperglycemia, hyperinsulinemia and hyperleptinemia in C57BL/6 mice.
Formal Description
Interaction-ID: 6501

environment

high-fat diet

increases_quantity of

gene/protein

LEP

in blood
Comment Resistance to leptin was confirmed as exogenous leptin administration reduced food intake in animals on low-fat, but not high-fat diets.
Formal Description
Interaction-ID: 6504

environment

high-fat diet

increases_activity of

phenotype

leptin resistance

Comment High fat feeding leads to hepatic insulin resistance and elevated PTP1B protein expression in liver, muscle and adipose tissue.
Formal Description
Interaction-ID: 6505

environment

high-fat diet

increases_activity of

disease

Insulin resistance

in liver
Comment High fat feeding leads to hepatic insulin resistance and elevated PTP1B protein expression in liver, muscle and adipose tissue.
Formal Description
Interaction-ID: 6506

environment

high-fat diet

increases_expression of

gene/protein

PTPN1

in liver, in muscle, in adipose tissue
Drugbank entries Show/Hide entries for PTPN1
Comment Adenovirus-mediated over-expression of PTP1B in livers of ob/ob mice has minimal effects on glucose homeostasis for 5 days after infection.
Formal Description
Interaction-ID: 6508

gene/protein

PTPN1

affects_activity of

if PTPN1 is overexpressed
Drugbank entries Show/Hide entries for PTPN1
Comment Increased PTP1B expression in livers of ob/ob mice inhibits the effects of leptin on food consumption and blood glucose concentrations.
Formal Description
Interaction-ID: 6509

gene/protein

PTPN1

decreases_activity of

gene/protein

LEP

if PTPN1 is overexpressed
Drugbank entries Show/Hide entries for PTPN1