General Information:

Id: 1,026 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
article
Reference: Zabolotny JM et al.(2008) Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J. Biol. Chem. 283 [PMID: 18281274]

Interaction Information:

Comment To ask whether TNF-alpha can promote PTP1B overexpression in insulin- and leptin-target tissues of mice, FVB mice were treated with TNF-alpha. Four hours after treatment, PTP1B mRNA levels were increased by 4.5-fold in liver, 1.8-fold in skeletal muscle, 1.6-fold in adipose tissue, and 1.4-fold in the arcuate nucleus. To determine whether TNF-alpha is necessary for PTP1B overexpression in insulin- and leptin-target tissues in mice with diet-induced obesity, the authors compared the level of PTP1B overexpression in TNF-alpha-deficient (TNF-alpha -/-) and wild-type (TNF-alpha +/+) mice with diet-induced obesity. PTP1B overexpression in TNF-alpha -/- mice was significantly lower in both female and male mice compared with TNF-alpha +/+ mice.
Formal Description
Interaction-ID: 6463

gene/protein

TNF

increases_expression of

gene/protein

PTPN1

in liver, in skeletal muscle, in adipose tissue, in arcuate nucleus; in FVB mice
Drugbank entries Show/Hide entries for TNF or PTPN1