General Information:

Id: 1,023 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Rattus norvegicus
Sprague-Dawley rat pups
primary neuronal culture
article
Reference: Chen J et al.(2005) SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling J. Biol. Chem. 280 [PMID: 16183991]

Interaction Information:

Comment SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.
Formal Description
Interaction-ID: 6377

gene/protein

SIRT1

decreases_quantity of

phenotype

amyloid beta deposits

in rat primary neuronal culture; (microglia-dependent amyloid beta toxicity)
Comment SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.
Formal Description
Interaction-ID: 6418

gene/protein

SIRT1

decreases_activity of

process

NF-kappaB signaling

Comment Overexpression of SIRT1 deacetylase and the addition of the SIRT1 agonist resveratrol markedly reduced NF-kappaB signaling stimulated by amyloid beta peptide and had strong neuroprotective effects.
Formal Description
Interaction-ID: 6420

drug/chemical compound

Resveratrol

increases_activity of

gene/protein

SIRT1

Drugbank entries Show/Hide entries for Resveratrol
Comment SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.
Formal Description
Interaction-ID: 106868

gene/protein

SIRT1

decreases_activity of

process

positive regulation of NF-kappaB transcription factor activity

in rat primary neuronal culture; (microglia-dependent amyloid beta toxicity)