General Information:

Id: 1,020 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
BTO:0000007 HEK-293 cell
article
Reference: Lin JH et al.(2007) IRE1 signaling affects cell fate during the unfolded protein response. Science 318: 944-949 [PMID: 17991856]

Interaction Information:

Comment ER stress (by thapsigargin) induces the expression of IRE1 (ERN1). IRE1 signaling decayes within 8 hours.
Formal Description
Interaction-ID: 6366

increases_quantity of

gene/protein

ERN1

Drugbank entries Show/Hide entries for ERN1
Comment ER stress (by thapsigargin) induces the cleavage of ATF6. The cytosolic fragment ATF6f is the active form of the transcription activator. ATF6f diminishes 20 hours after induction of ER stress.
Formal Description
Interaction-ID: 6368

increases_activity of

gene/protein

ATF6

Comment Induction of BiP (HSPA5) mRNA, encoding an HSP70-class ER chaperone that is transcriptionally regulated by both ATF6f and XBP-1s (spliced), peaked at 8 hours after drug treatment and then declined to near preinduction levels.
Formal Description
Interaction-ID: 6396

increases_expression of

gene/protein

HSPA5

Drugbank entries Show/Hide entries for HSPA5
Comment In contrast to IRE1 and ATF6, PERK (EIF2AK3) activation is largely sustained with unmitigated ER stress.
Formal Description
Interaction-ID: 6398

increases_activity of

gene/protein

EIF2AK3

Comment Aktivation of PERK during ER stress resulted in the accumulation of phosphorylated elF2alpha (EIF2S1) as well as continuous production of ATF4 and its transcriptional target Chop (DDIT3).
Formal Description
Interaction-ID: 6400

increases_activity of

gene/protein

EIF2S1

Comment Aktivation of PERK during ER stress resulted in the accumulation of phosphorylated elF2alpha (EIF2S1) as well as continuous production of ATF4 and its transcriptional target Chop (DDIT3).
Formal Description
Interaction-ID: 6401

increases_activity of

gene/protein

DDIT3

Comment Aktivation of PERK during ER stress resulted in the accumulation of phosphorylated elF2alpha (EIF2S1) as well as continuous production of ATF4 and its transcriptional target Chop (DDIT3).
Formal Description
Interaction-ID: 6402

increases_activity of

gene/protein

ATF4