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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	1,020 (click here to show other Interactions for entry)
Diseases:	Amyotrophic lateral sclerosis
Organism:	Homo sapiens
Tissue/Cell line:	BTO:0000007 HEK-293 cell
Publication type:	article
Reference:	Lin JH et al.(2007) IRE1 signaling affects cell fate during the unfolded protein response. Science 318: 944-949 [PMID: 17991856]

Interaction Information:

Comment	Aktivation of PERK during ER stress resulted in the accumulation of phosphorylated elF2alpha (EIF2S1) as well as continuous production of ATF4 and its transcriptional target Chop (DDIT3).
Formal Description Interaction-ID: 6401	process response to endoplasmic reticulum stress increases_activity of gene/protein DDIT3

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