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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	101 (click here to show other Interactions for entry)
Diseases:	Amyotrophic lateral sclerosis
Organism:	Mus musculus
Tissue/Cell line:	BTO:0004488 NSC-34 cell; BTO:0000312 motoneuron
Publication type:	article
Reference:	Nishitoh H et al.(2008) ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1 Genes Dev 22: 1451-1464 [PMID: 18519638]

Interaction Information:

Comment	SOD1mut triggers ER stress. SOD1mut (SOD1(A4V), SOD1(G85R), and SOD1(G93A)) but not wild-type SOD1 (SOD1wt) activated IRE1 and PERK.
Formal Description Interaction-ID: 337	gene/protein mutant SOD1-p.A4V affects_activity of process response to endoplasmic reticulum stress in motor neurons

Comment	SOD1mut triggers ER stress. SOD1mut (SOD1(A4V), SOD1(G85R), and SOD1(G93A)) but not wild-type SOD1 (SOD1wt) activated IRE1 and PERK.
Formal Description Interaction-ID: 342	gene/protein mutant SOD1-p.G85R affects_activity of process response to endoplasmic reticulum stress in motor neurons

Comment	SOD1mut triggers ER stress. SOD1mut (SOD1(A4V), SOD1(G85R), and SOD1(G93A)) but not wild-type SOD1 (SOD1wt) activated IRE1 and PERK.
Formal Description Interaction-ID: 343	gene/protein mutant SOD1-p.G93A affects_activity of process response to endoplasmic reticulum stress in motor neurons

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