General Information:

Id: 1,016
Diseases: Parkinson disease
Homo sapiens
BTO:0002181 HEK-293T cell
article
Reference: Zhong N and Xu J(2008) Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1alpha: regulation by SUMOylation and oxidation. Hum. Mol. Genet. 17: 3357-3367 [PMID: 18689799]

Interaction Information:

Comment DJ-1 and PGC-1alpha synergistically activate the MnSOD promoter.
Formal Description
Interaction-ID: 6332

gene/protein

PPARGC1A

increases_expression of

gene/protein

SOD2

Drugbank entries Show/Hide entries for SOD2
Comment DJ-1 and PGC-1alpha synergistically activate the MnSOD promoter.
Formal Description
Interaction-ID: 6335

gene/protein

PARK7

increases_activity of

gene/protein

PPARGC1A

Drugbank entries Show/Hide entries for PARK7
Comment PGC-1alpha interacts with PSF.
Formal Description
Interaction-ID: 6337

gene/protein

PPARGC1A

interacts (colocalizes) with

gene/protein

SFPQ

Comment DJ-1 inhibits the SUMOylation of PSF.
Formal Description
Interaction-ID: 6338

gene/protein

PARK7

decreases_ubiquitination/sumoylation of

gene/protein

SFPQ

Drugbank entries Show/Hide entries for PARK7
Comment DJ-1 inhibited the binding between PGC-1alpha and PSF (SFPQ).
Formal Description
Interaction-ID: 6339

gene/protein

PARK7

decreases_quantity of

complex/PPI

PGC1alpha-PSF complex

Drugbank entries Show/Hide entries for PARK7
Comment PSF inhibited the activation from the human MnSOD promoter by PGC-1alpha by 50%.
Formal Description
Interaction-ID: 6341

gene/protein

SFPQ

decreases_expression of

gene/protein

SOD2

if expression has been activated by PGC-1alpha
Drugbank entries Show/Hide entries for SOD2
Comment PSF inhibited the activation from the human MnSOD promoter by PGC-1alpha by 50%.
Formal Description
Interaction-ID: 6343

gene/protein

SFPQ

decreases_activity of

gene/protein

PPARGC1A

Comment DJ-1 does not interact with PGC-1alpha directly.
Formal Description
Interaction-ID: 6346

gene/protein

PARK7

NOT interacts (colocalizes) with

gene/protein

PPARGC1A

Drugbank entries Show/Hide entries for PARK7