General Information:

Id: 1,012 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
CHP-212, a human neuroblastoma cell line
Reference: Zhong N and Xu J(2008) Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1alpha: regulation by SUMOylation and oxidation Hum. Mol. Genet. 17: 3357-3367 [PMID: 18689799]

Interaction Information:

Comment Transfection of the DJ-1 siRNA reduced the protein levels of the endogenous DJ-1 by more than 70% and resulted in decrease of the mRNA expression of genes involved in reactive oxygen species (ROS) removal, such as MnSOD, catalase, glutamate cysteine ligase catalytic subunit (GCLC) and glutathione peroxidase 1 (Gpx1).
Formal Description
Interaction-ID: 6314



decreases_quantity of

drug/chemical compound

Reactive oxygen species

Drugbank entries Show/Hide entries for GPX1