General Information:

Id: 1,007 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
brain
article
Reference: Julien C et al.(2009) Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. J. Neuropathol. Exp. Neurol. 68: 48-58 [PMID: 19104446]

Interaction Information:

Comment A significant reduction of SIRT1 (mRNA: -29%, protein: -45%) in the parietal cortex of AD patients, but not in the cerebellum was observed.
Formal Description
Interaction-ID: 6284

decreases_expression of

gene/protein

SIRT1

in the parietal cortex of AD patients, but not in the cerebellum