General Information:

Id: 1,007 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
brain
article
Reference: Julien C et al.(2009) Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. J. Neuropathol. Exp. Neurol. 68: 48-58 [PMID: 19104446]

Interaction Information:

Comment A significant reduction of SIRT1 (mRNA: -29%, protein: -45%) in the parietal cortex of AD patients, but not in the cerebellum was observed.
Formal Description
Interaction-ID: 6284

decreases_expression of

gene/protein

SIRT1

in the parietal cortex of AD patients, but not in the cerebellum
Comment SIRT1 was decreased in the cortex of AD patients but not in individuals with mild cognitive impairment.
Formal Description
Interaction-ID: 29672

phenotype

mild cognitive impairment

NOT decreases_expression of

gene/protein

SIRT1

in the cortex of AD patients