General Information:

Id: 1,007
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
brain
article
Reference: Julien C et al.(2009) Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. J. Neuropathol. Exp. Neurol. 68: 48-58 [PMID: 19104446]

Interaction Information:

Comment A significant reduction of SIRT1 (mRNA: -29%, protein: -45%) in the parietal cortex of AD patients, but not in the cerebellum was observed.
Formal Description
Interaction-ID: 6284

decreases_expression of

gene/protein

SIRT1

in the parietal cortex of AD patients, but not in the cerebellum
Comment Patients with Alzheimer's disease experience a progressive loss of cognitive function.
Formal Description
Interaction-ID: 6285

increases_activity of

phenotype

cognitive impairment

Comment The loss of SIRT1 is closely associated with the accumulation of Abeta and tau in the cerebral cortex of patients with AD.
Formal Description
Interaction-ID: 6286

phenotype

decreased SIRT1 level

increases_quantity of

gene/protein

Amyloid beta peptide

in cerebral cortex of AD patients
Comment The loss of SIRT1 is closely associated with the accumulation of Abeta and tau in the cerebral cortex of patients with AD.
Formal Description
Interaction-ID: 6287

phenotype

decreased SIRT1 level

increases_quantity of

gene/protein

MAPT

in cerebral cortex of AD patients
Comment SIRT1 was decreased in the cortex of AD patients but not in individuals with mild cognitive impairment.
Formal Description
Interaction-ID: 29672

phenotype

mild cognitive impairment

NOT decreases_expression of

gene/protein

SIRT1

in the cortex of AD patients