General Information:

Id: 1,006
Diseases: Parkinson disease
Rattus norvegicus
BTO:0004032 dopaminergic neuron
article
Reference: Zhou W and Freed CR(2005) DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity J. Biol. Chem. 280 [PMID: 16227205]

Interaction Information:

Comment Expression of WT DJ-1 protects rat primary dopamine neurons from oxidative stress, whereas L166P DJ-1 did not protect.
Formal Description
Interaction-ID: 6273

gene/protein

PARK7

decreases_activity of

process

neuron death

induced by oxidative stress
Drugbank entries Show/Hide entries for PARK7
Comment Expression of WT DJ-1 protects rat primary dopamine neurons from oxidative stress, whereas L166P DJ-1 did not protect.
Formal Description
Interaction-ID: 6274

gene/protein mutant

PARK7-p.L166P

NOT decreases_activity of

process

neuron death

induced by oxidative stress
Comment Expression of WT DJ-1 protects rat primary dopamine neurons from oxidative stress, whereas L166P DJ-1 did not protect.
Formal Description
Interaction-ID: 6275

gene/protein

PARK7

decreases_activity of

induced by H2O2 or 6-OHDA
Drugbank entries Show/Hide entries for PARK7
Comment Expression of WT DJ-1 protects rat primary dopamine neurons from oxidative stress, whereas L166P DJ-1 did not protect.
Formal Description
Interaction-ID: 6276

gene/protein mutant

PARK7-p.L166P

NOT decreases_activity of

induced by H2O2 or 6-OHDA