General Information:

Id: 1,005 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Rattus norvegicus
BTO:0002393 N-27 cell
Reference: Zhou W and Freed CR(2005) DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity J. Biol. Chem. 280 [PMID: 16227205]

Interaction Information:

Comment Levels for Hsp70 mRNA were significantly increased in cells treated with WT DJ-1 and to a lesser extent, increased in A53T alpha-synuclein alone. The data suggest that DJ-1 inhibits A53T alpha-synuclein aggregation by increasing HSP70.
Formal Description
Interaction-ID: 6296



decreases_quantity of

by increasing HSP70, thus inhibiting SNCA aggregation
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